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Prostate-specific RNA aptamer: promising nucleic acid antibody-like cancer detection

15 Jul 2015

Abstract excerpt

We described the selection of a novel nucleic acid antibody-like prostate cancer (PCa) that specifically binds to the single-stranded DNA molecule from a 277-nt fragment that may have been partially paired and bound to the PCA3 RNA conformational structure. PCA3-277 aptamer ligands were obtained, and the best binding molecule, named CG3, was synthesized for validation. Aiming to prove its diagnostic utility, we...

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PMID: 26174796
DOI: 10.1038/srep12090

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