Article

Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine

2022-05-17

Abstract excerpt

<title>Abstract</title> <p>Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. This vaccine platform has been extended to encode an alphavirus replicase that self-amplifies the full length mRNA and SARS-CoV-2 spike (S) transgene (self-amplifying mRNA or sa mRNA). However, early phase clinical trials of sa-mRNA COVID-19 vaccine candidates have...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54e9b69f-203a-568a-a6be-3fc4c8624a47
DOI: 10.21203/rs.3.rs-1629079/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccineDOI 10.21203/rs.3.rs-1629079/v1Read

Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccineSemantic proximity Read

Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccineSemantic proximity Read

Sustained Humoral Activation through self-amplifying mRNA Vaccination Enhances Longitudinal Antibody Function in a Phase III TrialSemantic proximity Read

Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine DevelopmentSemantic proximity Read

sa-mRNA influenza vaccine raises a higher and more durable immune response than mRNA vaccine in preclinical modelsSemantic proximity Read

Profiling antibody epitopes induced by mRNA-1273 vaccination and boostersSemantic proximity Read

High temporal resolution systems profiling reveals distinct patterns of interferon response after Covid-19 mRNA vaccination and SARS-CoV2 infectionSemantic proximity Read

Self-Amplifying RNA: A Second Revolution of mRNA Vaccines against COVID-19Semantic proximity Read

A new mRNA antigen vaccine induces potent B and T cell responses and <i>in vivo</i> protection against SARS-CoV-2Semantic proximity Read

Systems biological assessment of human immunity to BNT162b2 mRNA vaccinationSemantic proximity Read

Shared Clinical and Immunologic Features of mRNA Vaccines: Preliminary Results from a Comparative Clinical StudySemantic proximity Read

Single-cell transcriptomic atlas of individuals receiving inactivated COVID-19 vaccines reveals distinct immunological responses between vaccine and natural SARS-CoV-2 infectionSemantic proximity Read