Article

Metabolic signatures of ferritin and TDP-43 co-pathology provide a mechanistic basis for stratified therapeutic approaches in ALS

2026-03-16

Abstract excerpt

<h4>Background</h4> ALS is increasingly recognized as a biologically heterogeneous disease in which several molecular and pathological mechanisms converge on a similar clinical phenotype. One of these molecular markers is ferritin accumulation which is observed in a subset of ALS cases and has been shown to directly correlate with TDP-43 pathology in some brain regions. Additionally, TDP-43 proteinopathy is obser...

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Literature Corpus work: 6a73fd27-1040-5a6f-8b02-2397f5e25ae1
DOI: 10.64898/2026.03.13.711539

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