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Article

Gene expression intensity shapes evolutionary rates of the proteins encoded by the vertebrate genome.

Genetics - 1 Sept 2004

Subramanian Sankar, Kumar Sudhir

Abstract excerpt

Natural selection leaves its footprints on protein-coding sequences by modulating their silent and replacement evolutionary rates. In highly expressed genes in invertebrates, these footprints are seen in the higher codon usage bias and lower synonymous divergence. In mammals, the highly expressed genes have a shorter gene length in the genome and the breadth of expression is known to constrain the rate of protein...

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Identifiers

PMID: 15454550
DOI: 10.1534/genetics.104.028944
PMCID: PMC1448110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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