Article
Toward the NMR structure of StAR.
Molecular and cellular endocrinology - 5 Mar 2009
Barbar Elie, Lehoux Jean-Guy, Lavigne Pierre
Abstract excerpt
The steroidogenic acute regulatory (StAR) protein plays a crucial role in steroidogenesis, as it accelerates the transport of cholesterol to the inner mitochondrial membrane where the cytochrome P450scc enzyme is located. Mutations in the StAR gene can lead to lipoid congenital adrenal hyperplasia (LCAH), a disease that is fatal if not treated with hormone replacement therapy. Solving the structure of StAR is an...
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