Article
Genetics of Epileptic Networks: from Focal to Generalized Genetic Epilepsies.
Current neurology and neuroscience reports - 13 Aug 2020
Qaiser Farah, Yuen Ryan K C, Andrade Danielle M
Abstract excerpt
PURPOSE OF REVIEW: Seizures can arise in neocortical, thalamocortical, limbic or brainstem networks. Here, we review recent genetic mechanisms implicated in focal and genetic generalized epilepsies (GGEs). RECENT FINDINGS: Pathogenic variation in GAP activity toward RAGs 1 (GATOR1) complex genes (i.e., DEPDC5, NPRL2 and NPRL3) mainly result in focal epilepsies. They are associated with high rates of sudden...
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