Article

Generative single-cell transcriptomics via large language models

2026-01-13

Abstract excerpt

<h4>ABSTRACT</h4> Single-cell and spatial transcriptomics have generated vast atlases of cellular states, yet these data are almost exclusively used for analysis rather than generation. Here we introduce the LLM-based model PGL, Portraying Gene Language, a framework that reframes single-cell transcriptomes as a language generation modeling problem. PGL represents each cell as a long sequence of gene–expression to...

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Literature Corpus work: 7ff4fd17-e845-516c-a696-e33d1b9af6d3
DOI: 10.64898/2026.01.12.699186

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