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Article

The Mechanism of SARS-CoV-2 Nucleocapsid Protein Recognition by the Human 14-3-3 Proteins.

Journal of molecular biology - 16 Apr 2021

Tugaeva Kristina V, Hawkins Dorothy E D P, Smith Jake L R, Bayfield Oliver W, Ker De-Sheng, Sysoev Andrey A, Klychnikov Oleg I, Antson Alfred A, Sluchanko Nikolai N

Abstract excerpt

The coronavirus nucleocapsid protein (N) controls viral genome packaging and contains numerous phosphorylation sites located within unstructured regions. Binding of phosphorylated SARS-CoV N to the host 14-3-3 protein in the cytoplasm was reported to regulate nucleocytoplasmic N shuttling. All seven isoforms of the human 14-3-3 are abundantly present in tissues vulnerable to SARS-CoV-2, where N can constitute up...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33556408
DOI: 10.1016/j.jmb.2021.166875
PMCID: PMC7863765

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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