Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate causal variants in macular degeneration.

Cell reports - 27 Jan 2026

Wang Sean K, Li Jiaying, Nair Surag, Kosaraju Reshma, Chen Yun, Zhang Yuanyuan, Kundaje Anshul, Liu Yuwen, Wang Ningli, Chang Howard Y

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of vision loss worldwide. Genome-wide association studies (GWASs) of AMD have identified dozens of risk loci that may house disease targets. However, variants at these loci are largely noncoding, making it difficult to assess their function and whether they are causal. Here, we present a single-cell gene expression and chromatin accessibility atlas of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Choroid
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Macular Degeneration

Share to Polymorphism, Single Nucleotide

Share to Retinal Pigment Epithelium

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 41528844
DOI: 10.1016/j.celrep.2025.116814
PMCID: PMC12971065

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate causal variants in macular degeneration.PMID 41528844Read ↗

Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate pathogenic variants in age-related macular degenerationSemantic proximity Read ↗

Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseasesSemantic proximity Read ↗

Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseasesSemantic proximity Read ↗

Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration.Semantic proximity Read ↗

An Integrated Multi-omics Single Cell Atlas of the Human RPE and ChoroidSemantic proximity Read ↗

Human iPSC-Derived Retinal Pigment Epithelium: A Model System for Prioritizing and Functionally Characterizing Causal Variants at AMD Risk LociSemantic proximity Read ↗

Single-cell quantitative trait loci analyses identify expression changes in macular degeneration risk genesSemantic proximity Read ↗

High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease lociSemantic proximity Read ↗

Human iPSC-derived retinal pigment epithelium: a model system for identifying and functionally characterizing causal variants at AMD risk lociSemantic proximity Read ↗

Single-cell analysis of the epigenome and 3D chromatin architecture in the human retinaSemantic proximity Read ↗

Integrated multi-omics single cell atlas of the human retinaSemantic proximity Read ↗

A systems biology approach uncovers novel disease mechanisms in age-related macular degenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.