Article

Integrative single cell multiomics analysis of human retina indicates a role for hierarchical transcription factors collaboration in genetic effects on gene regulation

2022-11-17

Abstract excerpt

<h4>Background</h4> Systematic characterization of how genetic variation modulates gene regulation in a cell type specific context is essential for understanding complex traits. To address this question, we profiled gene expression and chromatin state of cells from healthy retinae of 20 human donors with a single-cell multiomics approach, and performed genomic sequencing. <h4>Results</h4> We mapped single-cell e...

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Literature Corpus work: 646a98cf-ba65-5bab-b820-801d6a9088e2
DOI: 10.1101/2022.11.16.516814

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