Article

The impact of Fisher’s Reproductive Compensation on raising equilibrium frequencies of semi-dominant, non-lethal mutations under mutation/selection balance

2021-11-23

Abstract excerpt

Fisher’s reproductive compensation (fRC) occurs when a species’ demography means the death of an individual allows increased survival of his/her relatives, usually assumed to be full sibs. This likely occurs in many species, including humans. Several important recessive human genetic diseases cause early foetal/infant death allowing fRC to act on these mutations. The impact of fRC on these genetic conditions has b...

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Literature Corpus work: 697c3944-7e9c-5cb7-bdd9-f71e598db042
DOI: 10.1101/2021.11.19.469230

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