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The significance of cellular senescence hub genes in the diagnosis and subtype classification of a comprehensive database of gene expression in intervertebral disc degeneration

2022-11-17

Abstract excerpt

Intervertebral disc degeneration (IVDD) is a complex age-related physiological change involving mainly cellular senescence (CS), inflammation, impaired tissue biomechanical function, and degradation of the extracellular matrix, and is a major cause of lumbar disc herniation and low back pain. Nonetheless, the specific role of CS and its associated genes in IVDD remains unclear. In this study, we first obtained 53...

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Literature Corpus work
6976acbd-652f-510d-951a-930f9d9d053b
DOI
10.21203/rs.3.rs-2256275/v1
Open publication

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