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Identification and validation of ferroptosis-related gene signature in intervertebral disc degeneration

6 Feb 2023

Abstract excerpt

Lower back pain (LBP) is a leading cause of disability in the elderly and intervertebral disc degeneration (IDD) is the major contributor to LBP. Ferroptosis is a newly discovered programmed cell death, characterized by iron-dependent lethal lipid peroxidation. Growing evidence has shown that ferroptosis plays important roles in various human diseases. However, the underlying mechanism of ferroptosis in IDD...

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PMID: 36814575
DOI: 10.3389/fendo.2023.1089796

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