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Unraveling the pivotal role of cellular senescence genes in intervertebral disc degeneration: insights from bioinformatics analysis and experimental validation

2023-09-19

Abstract excerpt

Intervertebral disc degeneration (IVDD) is a complex age-related physiological change involving mainly cellular senescence (CS), inflammation, impaired tissue biomechanical function, and degradation of the extracellular matrix, and is a major cause of lumbar disc herniation and low back pain. Nonetheless, the specific role of CS and its associated genes in IVDD remains unclear. In this study, we first obtained 53...

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Literature Corpus work
256acc32-7001-57f3-ae74-85d74bc9ee91
DOI
10.21203/rs.3.rs-3340245/v1
Open publication

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