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Identification and validation of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration

29 May 2025

Abstract excerpt

Objective: To identify cell senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration (IVDD) using bioinformatics and investigate their biological functions and signaling pathways. Methods: GSE56081 and GSE23130 datasets were downloaded from the Gene Expression Omnibus (GEO) database. The former was used for the analysis of differentially expressed genes (DEGs) and...

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PMID: 40510349
DOI: 10.3389/fimmu.2025.1589849

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