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Article

Mechanistically distinct mouse models for CRX-associated retinopathy.

PLoS genetics - 1 Feb 2014

Tran Nicholas M, Zhang Alan, Zhang Xiaodong, Huecker Julie B, Hennig Anne K, Chen Shiming

Abstract excerpt

Cone-rod homeobox (CRX) protein is a "paired-like" homeodomain transcription factor that is essential for regulating rod and cone photoreceptor transcription. Mutations in human CRX are associated with the dominant retinopathies Retinitis Pigmentosa (RP), Cone-Rod Dystrophy (CoRD) and Leber Conge...

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Source

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Identifiers

PMID: 24516401
DOI: 10.1371/journal.pgen.1004111
PMCID: PMC3916252

Genes

CRX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24516401-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Mechanistically distinct mouse models for CRX-associated retinopathy.PMID 24516401Read ↗

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Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function.Semantic proximity Read ↗

OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness.Semantic proximity Read ↗

Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanismsSemantic proximity Read ↗

Pathogenic variants in Crx have distinct cis-regulatory effects on enhancers and silencers in photoreceptorsSemantic proximity Read ↗

Graded gene expression changes determine phenotype severity in mouse models of CRX-associated retinopathies.Semantic proximity Read ↗

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Cat LCA-CRX Model, Homozygous for an Antimorphic Mutation Has a Unique Phenotype.Semantic proximity Read ↗

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