Article

Structural and functional analysis of the human Cone-rod homeobox transcription factor

2022-01-09

Abstract excerpt

The cone-rod homeobox (CRX) protein is a critical K50 homeodomain transcription factor responsible for the differentiation and maintenance of photoreceptor neurons in the vertebrate retina. Mutant alleles in the human gene encoding CRX result in a variety of distinct blinding retinopathies, including retinitis pigmentosa, cone-rod dystrophy, and Leber congenital amaurosis. Despite the success of using in vitro bio...

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Literature Corpus work: ee9086ca-9c77-5191-9873-505449479403
DOI: 10.1101/2022.01.09.475544

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