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Modulation of novel drug targets in neurotransmitter signalling to eradicate leukaemic stem cells in chronic myeloid leukaemia

2019-01-01

Abstract excerpt

The most significant obstacle in developing a cure for chronic myeloid leukaemia (CML) is the existence of TKI-insensitive leukaemic stem cells (LSCs) in patients with residual disease. Previous transcriptomics analysis pointed to neurotransmitter pathways as being active in LSC and normal haematopoietic stem cells (HSCs), but significantly deregulated between them. It was therefore hypothesised that these pathway...

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Literature Corpus work
693d029f-4326-5d5b-956e-079a2ac20e5a
DOI
10.5525/gla.thesis.79052
Open publication

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