Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model

Abstract excerpt

The human brain displays substantial regional variability in molecular, anatomical, and physiological organization. Yet, how this heterogeneity shapes large-scale neuronal dynamics remains poorly understood. To address this question, we employed a biologically informed whole-brain computational model capable of generating distinct brain states, from awake-like to sleep-like regimes. Our model was constrained by em...

Topics

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• Action Potentials
• Advanced Neuroimaging Techniques and Applications
• Data Interpretation, Statistical
• Databases, Factual
• Hippocampus
• Models, Neurological
• Neurons
• Phenotype

Identifiers and source

Literature Corpus work

efb9f550-ee75-5bb8-ae45-df1c8812f72b

DOI

10.1101/2025.10.28.685048