Article
Regulation of the F11, Klkb1, Cyp4v3 gene cluster in livers of metabolically challenged mice.
PloS one - 1 Jan 2013
Safdar Huma, Cleuren Audrey C A, Cheung Ka Lei, Gonzalez Frank J, Vos Hans L, Inoue Yusuke, Reitsma Pieter H, van Vlijmen Bart J M
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in a 4q35.2 locus that harbors the coagulation factor XI (F11), prekallikrein (KLKB1), and a cytochrome P450 family member (CYP4V2) genes are associated with deep venous thrombosis (DVT). These SNPs exert their effect on DVT by modifying the circulating levels of FXI. However, SNPs associated with DVT were not necessarily all in F11, but also in KLKB1 and CYP4V2. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.