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Article

The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome.

BMC medical genetics - 9 Aug 2018

Jiang Yu-Liang, Zhao Zi-Ye, Li Bai-Rong, Yang Fu, Li Jing, Jin Xiao-Wei, Wang Hao, Yu En-Da, Sun Shu-Han, Ning Shou-Bin

Abstract excerpt

BACKGROUND: Peutz-Jeghers syndrome (PJS) is caused by mutations in serine/threonine kinase 11 (STK11) gene. The increased cancer risk has been connected to P53 pathway. METHODS: PJS probands with STK11 mutation were included in the function analysis. P53 activity elevated by STK11 mutants was investigated using dual-luciferase reporter assay in vitro after constructing expression vectors of STK11 wild type and...

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Identifiers

PMID: 30092773
DOI: 10.1186/s12881-018-0626-5
PMCID: PMC6085611

Genes

STK11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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