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Article

An exploration of genotype-phenotype link between Peutz-Jeghers syndrome and STK11: a review.

Familial cancer - 1 Jul 2018

Daniell Julian, Plazzer John-Paul, Perera Anuradha, Macrae Finlay

Abstract excerpt

Peutz-Jeghers Syndrome (PJS) is an autosomal dominant hereditary polyposis syndrome. Clinical features include hamartomatous polyps, mucocutaneous pigmentation and an increased predisposition towards developing malignancy. Variants in STK11, a tumour suppressor gene, located on Chromosome 19, predispose to PJS. Peutz-Jeghers Syndrome is associated with increased rates of malignancy, particularly gastrointestinal....

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Identifiers

PMID: 28900777
DOI: 10.1007/s10689-017-0037-3

Genes

STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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