Article

Gatekeeper transcription factors regulate switch between lineage preservation and cell plasticity

2020-03-20

Abstract excerpt

<h4>Summary</h4> Reprogramming somatic cells to pluripotency by repressing lineage-instructive transcription factors (TFs) alone has not been pursued because lineage specification is thought to be regulated by transcriptional regulatory networks (TRNs) comprising of multiple TFs rather than by single pivotal “gatekeeper” TFs. Utilizing an intra-species somatic cell hybrid model, we identified Snai2 and Prrx1 as t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68ac56c5-83c2-53ba-b3e0-63d608c7cf04
DOI: 10.1101/2020.03.19.999433

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gatekeeper transcription factors regulate switch between lineage preservation and cell plasticityDOI 10.1101/2020.03.19.999433Read

Epigenetic reprogramming of cell identity: lessons from development for regenerative medicineSemantic proximity Read

Direct cell-fate conversion of somatic cells: Toward regenerative medicine and industriesSemantic proximity Read

Cellular reprogramming – lowering gravity on Waddington's epigenetic landscapeSemantic proximity Read

Activin/nodal signalling controls the epigenome and epitranscriptome of human pluripotent stem cellsSemantic proximity Read

Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated CellsSemantic proximity Read

Distinguishing Between Mouse and Human Pluripotent Stem Cell Regulation: The Best Laid Plans of Mice and MenSemantic proximity Read

Induced Pluripotent Stem Cells: Fundamentals and Applications of the Reprogramming Process and its Ramifications on Regenerative MedicineSemantic proximity Read

A fast 2C-induction method reveals a barrier role of SP2 for totipotencySemantic proximity Read

Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selectionSemantic proximity Read

Engineering Cell Fate: The Roles of iPSC Transcription Factors, Chemicals, Barriers and Enhancing Factors in Reprogramming and TransdifferentiationSemantic proximity Read

A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations.Semantic proximity Read

Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-AzacytidineSemantic proximity Read