Article

Non-conserved metabolic regulation by LKB1 distinguishes human and mouse lung adenocarcinoma

2021-10-02

Abstract excerpt

KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD) and activating mutations in KRAS frequently co-occur with loss-of-function mutations in the tumor suppressor genes, TP53 or STK11/LKB1 . However, mutation of all three genes is rarely observed in hLUAD, even though engineered mutations of all three genes produces a highly aggressive lung adenocarcinoma in mice (mLUAD). Here we pro...

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Literature Corpus work: 689b3fd0-c517-57e9-980b-ef6ae715f319
DOI: 10.1101/2021.10.01.462764

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