Article
Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities.
Nature - 3 Mar 2016
Kerr Emma M, Gaude Edoardo, Turrell Frances K, Frezza Christian, Martins Carla P
Abstract excerpt
The RAS/MAPK (mitogen-activated protein kinase) signalling pathway is frequently deregulated in non-small-cell lung cancer, often through KRAS activating mutations. A single endogenous mutant Kras allele is sufficient to promote lung tumour formation in mice but malignant progression requires additional genetic alterations. We recently showed that advanced lung tumours from Kras(G12D/+);p53-null mice frequently...
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