Article

Dynamics of gene expression and chromatin marking during cell state transition

2020-11-20

Abstract excerpt

<h4>Summary</h4> We have monitored the transcriptomic and epigenomic status of cells at twelve time-points during the transdifferentiation of human pre-B cells into macrophages. Using this data, we have investigated some fundamental questions regarding the role of chromatin in gene expression. We have found that, over time, genes are characterized by a limited number of chromatin states (combinations of histone m...

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Literature Corpus work: 686e8d38-aa98-5ce4-9c47-ca6d763a08b4
DOI: 10.1101/2020.11.20.391524

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