Article

CRISPR/Cas9-mediated Generation of <i>COL7A1</i> -deficient Keratinocyte Model of Recessive Dystrophic Epidermolysis Bullosa

2023-06-16

Abstract excerpt

<h4>Objective</h4> Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility and ultimately lethal blistering disease caused by mutations in the COL7A1 gene which is responsible for coding type VII collagen. Investigating the pathological mechanisms and novel candidate therapies for RDEB could be fostered by new cellular models. Here, we developed multiple immortalized COL7A1 -deficient kera...

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Literature Corpus work: 8d03f634-05ae-5164-b936-8bffb665a3d6
DOI: 10.1101/2023.06.15.545036

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