Integrating mutational and nonmutational mechanisms of acquired therapy resistance within the Darwinian paradigm.

Abstract excerpt

Mutational processes and nongenetic phenotypic state transitions represent distinct paradigms for understanding acquired resistance to targeted therapies. While ample empirical evidence supports both paradigms, they are typically viewed as mutually exclusive. However, a growing body of evidence points to the multifactorial nature of resistance, where resistant tumor cell phenotypes integrate the influence of...

Topics

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• Drug Resistance, Neoplasm
• Epigenesis, Genetic
• Mutation
• Neoplasms
• Phenotype