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Article

New perspectives on epigenetic modifications and PARP inhibitor resistance in HR-deficient cancers

1 Jan 2023

Abstract excerpt

The clinical treatment of DNA-repair defective tumours has been revolutionised by the use of poly(ADP) ribose polymerase (PARP) inhibitors. However, the efficacy of these compounds is hampered by resistance, which is attributed to numerous mechanisms including rewiring of the DNA damage response to favour pathways that repair PARP inhibitor-mediated damage. Here, we comment on recent findings by our group...

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Identifiers

PMID: 37065862
DOI: 10.20517/cdr.2022.73

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