Article

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition

2022-09-27

Abstract excerpt

<title>Abstract</title> <p>Acute myeloid leukemia (AML) is a heterogeneous, aggressive malignancy with dismal prognosis and with limited availability of targeted therapies. Epigenetic deregulation contributes to AML pathogenesis. KDM6 proteins are histone-3-lysine-27-demethylases that play context-dependent roles in AML. We inform that KDM6-demethylase function critically regulates DNA-damage-repair-(DDR) gene ex...

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Literature Corpus work: 2d656b34-2b73-5800-8fc2-0b59d74abe91
DOI: 10.21203/rs.3.rs-2064697/v1

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