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Article

Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.

Journal of the American Society of Nephrology : JASN - 1 Mar 2010

Shillingford Jonathan M, Piontek Klaus B, Germino Gregory G, Weimbs Thomas

Abstract excerpt

Aberrant activation of the mammalian target of rapamycin (mTOR) pathway occurs in polycystic kidney disease (PKD). mTOR inhibitors, such as rapamycin, are highly effective in several rodent models of PKD, but these models result from mutations in genes other than Pkd1 and Pkd2, which are the prim...

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Identifiers

PMID: 20075061
DOI: 10.1681/ASN.2009040421
PMCID: PMC2831854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20075061-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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