Article

Inferring and simulating a gene regulatory network for the sympathoadrenal differentiation from single-cell transcriptomics in human

2025-03-24

Abstract excerpt

<h4>Background</h4> Neuroblastoma is a malignant childhood cancer with significant inter- and intrapatient heterogeneity arising from the abnormal differentiation of neural crest cells into sympathetic neurons. The lack of actionable mutations limits therapeutic options, highlighting the need to better understand the molecular mechanisms that drive this differentiation. Although RNA velocity has provided some ins...

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Literature Corpus work: 34ffd9b8-08ee-57df-9bc5-74844c649a1d
DOI: 10.1101/2025.03.21.644507

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