Article

Utilizing Intraindividual Cognitive Variability to Predict Early Neuronal Synuclein Disease Progression

2025-10-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Neuronal synuclein disease (NSD) involves pathological α-synuclein presence and often dopaminergic dysfunction, initially preceding overt clinical symptoms. NSD-ISS identifies Stage 2A (no dopaminergic dysfunction) and 2B (dopaminergic dysfunction) as prodromal phases marked by subtle clinical signs without functional impairment. Intraindividual variability/dispersion (IIV-D...

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Literature Corpus work: 6791c2a1-aca4-5471-b7ee-2b22f2b7e6fb
DOI: 10.1101/2025.10.21.25338482

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