Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alzheimer's Polygenic Risk and Clinical Severity Manifest in Greater Cognitive Intra-Individual Variability.

Journal of the International Neuropsychological Society : JINS - 1 May 2025

Tan Chin Hong

Abstract excerpt

OBJECTIVE: Cognitive intra-individual variability (IIV) is a neuropsychological marker reflecting divergent performance across cognitive domains. In this brief communication, we examined whether clinical severity, apolipoprotein E (APOE) ε4 carriers, and higher polygenic risk were associated with higher cognitive IIV, and whether higher polygenic risk and cognitive IIV synergistically influence clinical severity....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Cognitive Dysfunction

Share to Multifactorial Inheritance

Share to Neuropsychological Tests

Share to Severity of Illness Index

Source

Identifiers

PMID: 40827747
DOI: 10.1017/S1355617725101252

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer's Polygenic Risk and Clinical Severity Manifest in Greater Cognitive Intra-Individual Variability.PMID 40827747Read ↗

Endophenotype-based polygenic risk scores: Prediction of biomarker and clinical progression and dementiaSemantic proximity Read ↗

Utilizing Intraindividual Cognitive Variability to Predict Early Neuronal Synuclein Disease ProgressionSemantic proximity Read ↗

Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment.Semantic proximity Read ↗

Alzheimer’s environmental and genetic risk scores are differentially associated with ‘g’ and δSemantic proximity Read ↗

Intra-individual variability across neuropsychological tasks in schizophrenia: a comparison of patients, their siblings, and healthy controls.Semantic proximity Read ↗

Heterogeneity and Factorial Structure in Alzheimer's Disease: A Cognitive Perspective.Semantic proximity Read ↗

The Role of Alzheimer's and Cerebrovascular Pathology in Mediating the Effects of Age, Race, and Apolipoprotein E Genotype on Dementia Severity in Pathologically-Confirmed Alzheimer's Disease.Semantic proximity Read ↗

Population-specific polygenic risk for Alzheimer’s disease is associated with Mini-Mental State Examination-based cognitive decline in a Japanese cohortSemantic proximity Read ↗

Neuroticism polygenic risk predicts conversion from mild cognitive impairment to Alzheimer's disease by impairing inferior parietal surface area.Semantic proximity Read ↗

Graded multidimensional clinical and radiological variation in patients with Alzheimer’s disease and posterior cortical atrophySemantic proximity Read ↗

Multidimensional cognitive deficits in the typical and atypical variants of Alzheimer’s diseaseSemantic proximity Read ↗

The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.