Article

Aging affects reprogramming of murine pulmonary capillary endothelial cells after lung injury

2023-07-12

Abstract excerpt

<h4>ABSTRACT</h4> Aging increases the risk of developing fibrotic diseases by hampering tissue regeneration after injury. Using longitudinal single-cell RNA-seq and spatial transcriptomics, here we compare the transcriptome of bleomycin-induced fibrotic lungs of young and aged mice, at 3 time points corresponding to the peak of fibrosis, regeneration and resolution. We find that lung injury shifts the transcripto...

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Literature Corpus work: 675dcfef-d587-5f05-b609-8373e36070d3
DOI: 10.1101/2023.07.11.548522

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