Article

Increase of fibrosis-related genes in doxorubicin-induced senescent human dermal fibroblasts but their secretome does not trigger a paracrine fibrotic response in non-senescent cells

2022-10-11

Abstract excerpt

Tissue fibrosis is associated with the aging process of most of our organs, and organ aging correlates with the chronic accumulation of senescent cells. Fibrosis occurs when fibroblasts proliferate and deposit pathological amounts of extracellular matrix (ECM), leading to progressive tissue scarring and organ dysfunction. Fibroblasts play a key role in fibrosis, especially in the skin where fibroblasts are the mos...

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Literature Corpus work: 67579e31-94a6-571d-8ef0-2da63a5b79e6
DOI: 10.21203/rs.3.rs-2134837/v1

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