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Targeting Dermal Fibroblast Senescence: From Cellular Plasticity to Anti-Aging Therapies

7 Aug 2025

Abstract excerpt

Dermal fibroblasts, the primary stromal cells of the dermis, exhibit remarkable plasticity in response to various stimuli, playing crucial roles in tissue homeostasis, wound healing, and ECM production. This study examines the molecular mechanisms underlying fibroblast plasticity, including key signaling pathways, epigenetic regulation, and microRNA-mediated control. The impact of aging on ECM synthesis and...

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PMID: 40868181
DOI: 10.3390/biomedicines13081927

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