Article

Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth

2023-08-30

Abstract excerpt

Human silencers have been shown to exist and regulate developmental gene expression. However, the functional importance of human silencers needs to be elucidated, such as whether they can form “super-silencers” and whether they are linked to cancer progression. Here, through interrogating two putative silencer components of FGF18 gene, we found that two nearby silencers can cooperate via compensatory chromatin in...

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Literature Corpus work: 6706e324-a0ed-5db6-9a8b-e8feda7d2262
DOI: 10.1101/2023.08.29.555291

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