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Article

EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53.

Cancer letters - 9 Aug 2013

Seward Shelly, Semaan Assaad, Qazi Aamer M, Gruzdyn Oksana V, Chamala Sreedhar, Bryant Christopher C, Kumar Sanjeev, Cameron David, Sethi Seema, Ali-Fehmi Rouba, Morris Robert, Bouwman David L, Munkarah Adnan R, Weaver Donald W, Gruber Scott A, Batchu Ramesh B

Abstract excerpt

The enhancer of zeste homolog 2 (EZH2) methyltransferase is a transcriptional repressor. EZH2 is abnormally elevated in epithelial ovarian cancer (EOC). We demonstrated that EZH2 knockdown inhibited cell growth, activated apoptosis, and enhanced chemosensitivity. Further, silencing of EZH2 resulted in re-expression of p21(waf1/cip1) and down-regulation of mutant p53. Finally, EZH2 knockdown contributed to...

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PMID: 23603558
DOI: 10.1016/j.canlet.2013.04.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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