Article

Super-silencers regulated by chromatin interactions control apoptotic genes

2022-01-18

Abstract excerpt

<h4>Summary</h4> Human silencers have been shown to exist and regulate developmental gene expression. However, the functional importance of human silencers needs to be elucidated such as the working mechanism and whether they can form “super-silencers”. Here, through interrogating two putative silencer components of FGF18 gene, we found that two silencers can cooperate via compensated chromatin interactions to f...

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Literature Corpus work: d6ff7c81-dd8b-5c8f-adf2-cc66dcdc8964
DOI: 10.1101/2022.01.17.476559

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