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Article

A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells

1 Jan 2018

Abstract excerpt

We describe an expanded modular gastrointestinal (GI) tract-liver system by co-culture of primary human intestinal epithelial cells (hIECs) and 3D liver mimic. The two organ body-on-chip design consisted of GI and liver tissue compartments that were connected by fluidic medium flow driven via gravity. The hIECs and HepG2 C3A liver cells in the co-culture system maintained high viability for at least 14 days in...

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PMID: 29881844
DOI: 10.1039/c8lc00111a

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