Diseases and their clinical heterogeneity - Are we ignoring the SNiPers and micRomaNAgers? An illustration using Beta-thalassemia clinical spectrum and fetal hemoglobin levels.

Abstract excerpt

Diseases and pathological ailments are known to perplex clinicians and researchers with their varied clinical manifestations. Such variations are mostly attributed to the complex interplays between numerous molecular players and their modifiers. This complexity in turn baffles scientists further to tweak multiple players together when attempting to identify definitive therapeutic interventions. In this pursuit,...

Topics

• CpG Islands
• Databases, Genetic
• Fetal Hemoglobin
• Gene Expression Regulation
• Genetic Heterogeneity
• Genetic Profile