Article

Inhibition of Sphingosine Kinase 2 Down-Regulates ERK/c-Myc Pathway and Reduces Cell Proliferation in Human Epithelial Ovarian Cancer

2020-07-02

Abstract excerpt

<h4>Background: </h4> Epithelial ovarian cancer (EOC) is the leading cause of death from female cancers. In our previous study, Sphingosine kinase 2 (SphK2) inhibitor was shown to display anti-EOC activities. The purpose of this study was to further evaluate the expression characteristics and clinical significance of SphK2 in EOC, and to explore the roles and underlying mechanisms of SphK2 in EOC cell survival. <h...

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Literature Corpus work: 66d182e9-277e-5c76-8679-bfcbd384622d
DOI: 10.21203/rs.3.rs-38991/v1

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