Article

Inhibition of Sphingosine-1-Phosphate signaling in pancreatic ductal adenocarcinoma leads to downregulation of growth and invasion

2020-10-01

Abstract excerpt

<h4>Background</h4> Deregulated phosphorylation of sphingosine by the sphingosine kinases and signaling through the EDG family of receptors enhances growth and survival in many cell types. Therefore, we sought to elucidate the effect of alterations in the ceramide/sphingosine/S1P rheostat on driving human pancreatic ductal adenocarcinoma towards a malignant phenotype. <h4>Methods</h4> Pancreatic cancer cell line...

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Literature Corpus work: 3fd671de-0982-53a5-becf-c57d26956f8c
DOI: 10.1101/2020.09.29.318964

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