Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy

Abstract excerpt

Our understanding of the molecular basis of aging has greatly increased over the past few decades. In this review, we provide an overview of the key signaling pathways associated with aging, and whose modulation has been shown to extend lifespan in a range of model organisms. We also describe how these pathways converge onto autophagy, a catabolic process that functions to recycle dysfunctional cellular material...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Genetics, Aging, and Longevity in Model Organisms
• Share to Sirtuins and Resveratrol in Medicine