Article
2,5-Dimethyl-Celecoxib Extends Drosophila Life Span via a Mechanism That Requires Insulin and Target of Rapamycin Signaling.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Oct 2017
Wu Qi, Lian Ting, Fan Xiaolan, Song Chaochun, Gaur Uma, Mao Xueping, Yang Deying, Piper Matthew D W, Yang Mingyao
Abstract excerpt
The search for antiaging drugs is a key component of gerontology research. A few drugs with positive effects on life span in model organisms have been found. Here, we report that 2,5-dimethyl-celecoxib, a derivative of the anti-inflammatory drug celecoxib, can extend Drosophila life span and delay aging by a mechanism involving insulin signaling and target of rapamycin signaling. Importantly, its positive effects...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.