Article

Targeting the DNA damage response network as a therapeutical strategy in ovarian and pancreatic cancers

2015-01-01

Abstract excerpt

High grade serous (HGS) epithelial ovarian cancer (EOC) and pancreatic ductal adenocarcinoma (PDAC) are among the poorest prognosis neoplasms; both are characterised by defects in DNA damage repair mechanisms, high levels of genomic instability, intra-tumoural heterogeneity and resistance, intrinsic or acquired, to conventional chemotherapy. The DNA damaging agents, gemcitabine and platinum are standard treatments...

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Literature Corpus work: 4de21c98-922e-511a-b4c7-cdd2085b6c4b
DOI: 10.25560/29843

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