Back to search

Article

Inter-organ communication shapes human metabolic tissue states and resolves anti-diabetic drug response modes in a six-tissue microphysiological system

2026-05-27

Abstract excerpt

Systemic glucose regulation depends on coordinated signaling among metabolically specialized tissues, yet most human in vitro models capture only limited portions of this network. Here, we developed and benchmarked a perfused human six-tissue MPS by combining AnthroHive, a recirculating perfusion platform, with MOTIVE-6, a six-compartment Multiorgan Tissue Interaction Vessel, to culture human gut epithelium, panc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
667b47e1-4fc4-5363-a683-271a41c3ca55
DOI
10.64898/2026.05.22.726943
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Inter-organ communication shapes human metabolic tissue states and resolves anti-diabetic drug response modes in a six-tissue microphysiological systemDOI 10.64898/2026.05.22.726943
Diseased human pancreas and liver microphysiological system for preclinical diabetes researchSemantic proximity
From the Incretin System to the Entero–Pancreatico–Hepatico–Systemic Polyhormonal Metabolic Homeostasis NetworkSemantic proximity
From the Incretin System to the Entero–Pancreatico–Hepatico–Systemic Polyhormonal Metabolic Homeostasis NetworkSemantic proximity
A Microphysiological Model of Progressive Human Hepatic Insulin ResistanceSemantic proximity
Thermo-Dynamic Flux Balance Analysis, a novel approach to simulate circadian metabolismSemantic proximity
Integrating Machine Learning with Metabolic Models for Precision Trauma Care: Personalized ENDOTYPE Stratification and Metabolic Target IdentificationSemantic proximity
Integrating Machine Learning with Metabolic Models for Precision Trauma Care: Personalized ENDOTYPE Stratification and Metabolic Target IdentificationSemantic proximity
Signatures of medications in meditation: A Connectivity map analysis of transcriptomes from an inner engineering retreatSemantic proximity
A graph-based framework for multi-scale modeling of physiological transportSemantic proximity
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.Semantic proximity
Combination of triheptanoin with the ketogenic diet in Glucose transporter type 1 deficiency (G1D)Semantic proximity
Select a neighboring publication to make it the new centre.