Article

Genomic drivers of large B-cell lymphoma resistance to CD19 CAR-T therapy

2021-08-26

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric antigen receptor-reprogrammed autologous T cells directed to CD19 are breakthrough immunotherapies for heavily pretreated patients with aggressive B-cell lymphomas but still fail to cure most patients. Host inflammatory and tumor microenvironmental factors associate with CAR-19 resistance, but the tumor-intrinsic factors underlying these phenomena remain undefined. To characterize genom...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c67c6c4-254b-5853-b391-6835bedecf93
DOI: 10.1101/2021.08.25.457649

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic drivers of large B-cell lymphoma resistance to CD19 CAR-T therapyDOI 10.1101/2021.08.25.457649Read

Whole-genome sequencing reveals complex genomic features underlying anti-CD19 CAR T-cell treatment failures in lymphomaSemantic proximity Read

<i>RHOA</i> Deletion Downregulates CD19 and Promotes Dysfunctional Immune Microenvironments in CAR-T Resistant B-Cell LymphomaSemantic proximity Read

CD22-CAR T cell multiomic features linked to patient outcomes in CD19-CAR resistant large B cell lymphomaSemantic proximity Read

Impact of TP53 Genomic Alterations in Large B-Cell Lymphoma Treated With CD19-Chimeric Antigen Receptor T-Cell Therapy.Semantic proximity Read

CAR19 therapy drives expansion of clonal hematopoiesis and associated cytopeniasSemantic proximity Read

First generation anti-CD19 chimeric antigen receptor-modified T cells for management of B cell malignances: initial analysis of an ongoing Phase I clinical trialSemantic proximity Read

Multiomic study of cutaneous T-cell lymphoma reveals single-cell clonal evolution in progression and therapy resistance.Semantic proximity Read

Distinct cellular dynamics associated with response to CAR-T therapy for refractory B-cell lymphomaSemantic proximity Read

Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell MalignanciesSemantic proximity Read

The CD19 CAR T hinge region influences avidity and cytotoxicity in CD19 SNP variants in B-cell LymphomaSemantic proximity Read

The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignanciesSemantic proximity Read

Single-cell genomics links CAR architectures to in vivo effector chromatin states in T cells responding to antigen-low leukemiaSemantic proximity Read