Article

Kidney organoids: A system to study human basement membrane assembly in health and disease

2021-06-29

Abstract excerpt

<h4>SUMMARY</h4> Basement membranes (BMs) are complex macromolecular networks underlying all continuous layers of cells. Essential components include type IV collagen and laminins, which are affected by human genetic defects leading to a range of debilitating conditions including kidney, muscle, and cerebrovascular phenotypes. We investigated the dynamics of BM assembly in human pluripotent stem cell-derived kidn...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b556e985-4436-50dd-a0bb-5a83d5ba8aac
DOI: 10.1101/2021.06.27.450067

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Kidney organoids: A system to study human basement membrane assembly in health and diseaseDOI 10.1101/2021.06.27.450067Read

Basement Membrane Structural Integrity Dictates Trans-Tissue Deposition of Laminin in MammalsSemantic proximity Read

A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associationsSemantic proximity Read

Collagen IV of basement membranes: II. Emergence of collagen IVα345 enabled the assembly of a compact GBM as an ultrafilter in mammalian kidneysSemantic proximity Read

Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling metazoan multicellularity, evolution, and adaptationSemantic proximity Read

The nature and biology of basement membranes.Semantic proximity Read

Atypical basement membranes and basement membrane diversity – what is normal anyway?Semantic proximity Read

Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling animal evolution and adaptationSemantic proximity Read

Basement membranes in development and diseaseSemantic proximity Read

Single-cell analysis reveals congruence between kidney organoids and human fetal kidneySemantic proximity Read

Kidney organoids in translational medicine: Disease modeling and regenerative medicineSemantic proximity Read

3D Mapping Reveals a Complex and Transient Interstitial Matrix During Murine Kidney DevelopmentSemantic proximity Read

Polymerizing laminins in development, health, and disease.Semantic proximity Read